Lipoprotein (a) and cardiovascular risk in familial combined hyperlipidaemia: does it exist?
نویسندگان
چکیده
Abstract Background Previous studies suggest there is an association between levels of lipoprotein a [Lp (a)] and increased cardiovascular risk in general population familial hypercholesterolaemia patients. The purpose this study was to define the exact relationship Lp (a) Familial Combined Hyperlipidaemia (FCH) population. Methods We enrolled 1094 (615 males, mean age 49 years old) patients who fulfilled FCH criteria, from outpatient lipid clinic our hospital. were measured information obtained regarding demographic characteristics, presence coronary artery disease (CAD) CAD factors. Patients categorized initially according baseline quintile 1 (≤30mg/dl) (N=769), 2 (>30 mg/dl, ≤50mg/dl) (N=149), 3 (>50mg/dl, ≤100mg/dl) (N=124), 4 (>100mg/dl, ≤150mg/dl) (N=31), 5 (>150mg/dl) (N=21). calculated percentage with each quintile. Additionally, we performed logistic regression analysis predict based on other factors, age, sex, diabetes mellitus, hypertension smoking. Results Mean value for whole 29.67mg/dl. percentages 13.1%, 16.8%, 15.3%, 22.6%, 23.8% respectively quintiles 1–5 (Figure 1). number increases as increase. To further support finding, revealed that gender added significantly model. could CAD, independently Conclusions correlation unclear. There increasing trend higher positive relationship, indicating straightforward these two parameters. Funding Acknowledgement Type funding sources: None.
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2021
ISSN: ['2634-3916']
DOI: https://doi.org/10.1093/eurheartj/ehab724.2579